Last position-specific scoring matrix computed, weighted observed percentages rounded down, information per position, and relative weight of gapless real matches to pseudocounts A R N D C Q E G H I L K M F P S T W Y V A R N D C Q E G H I L K M F P S T W Y V 1 M -2 -2 -3 -4 -2 -1 -3 -4 -2 0 1 -2 8 -1 -3 -2 -1 -2 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0.99 0.14 2 Y -1 0 -2 -3 -2 -2 -2 -3 4 0 -1 -2 -1 0 -3 -1 -1 5 4 3 0 5 0 0 0 0 0 0 15 0 0 0 0 0 0 5 0 11 26 37 0.42 0.09 3 H -2 0 -1 -2 -4 2 0 -3 5 -4 -3 5 -2 -4 -2 -1 2 -4 -2 -3 0 0 0 0 0 11 0 0 18 0 0 54 0 0 0 0 17 0 0 0 0.72 0.21 4 V -2 -4 -4 -5 -2 -4 -4 -5 -5 4 0 -4 0 -2 -4 -3 -1 -4 -2 5 0 0 0 0 0 0 0 0 0 28 0 0 0 0 0 0 0 0 0 72 0.92 0.24 5 I 3 -1 -2 -3 -2 -1 -2 0 -3 2 -1 -1 1 -2 -2 -1 -1 -3 -2 2 39 2 2 0 0 3 0 5 0 19 0 3 4 0 0 0 0 0 0 24 0.26 0.13 6 A 1 -3 -3 -4 1 -3 -3 -3 -4 3 1 -3 0 -2 -3 -1 -1 -4 -2 4 16 0 0 0 3 0 0 0 0 23 8 0 0 0 0 5 0 0 0 45 0.42 0.14 7 A 3 -3 -2 -2 -2 -2 -2 4 -3 -3 -3 -2 -3 -4 -2 1 1 -4 -3 -2 42 0 0 0 0 0 0 43 0 0 0 0 0 0 0 5 9 0 0 0 0.71 0.19 8 T -1 -2 -1 -2 -2 -2 -2 -2 -3 -3 -3 -2 -2 -4 -2 5 5 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 57 43 0 0 0 0.90 0.27 9 T -1 2 1 -1 -3 1 -1 -2 -2 -1 -1 2 -1 -3 -2 0 3 -3 -2 -1 2 17 9 2 0 6 0 2 0 3 3 20 0 0 0 3 28 0 0 4 0.28 0.11 10 N -3 -2 8 0 -4 -1 -2 -2 -1 -5 -5 1 -4 -5 -4 -1 -2 -5 -4 -5 0 0 91 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 1.57 0.34 11 P -2 -1 -3 -2 -4 -2 2 -4 -3 -4 -4 -1 -4 -5 7 0 -2 -5 -4 -4 0 4 0 0 0 0 14 0 0 0 0 2 0 0 74 5 0 0 0 0 1.76 0.29 12 A 3 -3 1 -2 -2 -2 -2 -2 -3 0 -1 -2 -1 -3 -2 0 0 -4 -3 3 45 0 11 0 0 0 0 0 0 3 0 0 0 0 0 3 6 0 0 31 0.39 0.17 13 K -2 1 -2 -2 -5 0 -1 -3 -2 -4 -4 7 -3 -5 -3 -2 -2 -5 -4 -4 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 1.48 0.34 14 I -2 -4 -4 -4 -2 -4 -4 -5 -4 5 1 -4 0 -1 -4 -3 -2 -3 0 4 0 0 0 0 0 0 0 0 0 53 11 0 0 0 0 0 0 0 3 33 0.73 0.19 15 N 0 3 3 -1 -3 3 2 -2 1 -3 -3 2 -2 -4 -2 0 -1 -4 -2 -3 9 16 18 0 0 15 12 0 4 0 0 17 0 0 0 7 2 0 0 0 0.39 0.12 16 A 6 -3 -3 -3 -2 -2 -2 0 -3 -3 -3 -2 -2 -4 -2 0 -2 -4 -3 -2 97 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 1.13 0.30 17 I 0 -3 -3 -4 -2 -3 -3 -4 -4 3 0 -3 0 -2 -3 -2 2 -4 -2 4 9 0 0 0 0 0 0 0 0 23 4 0 0 0 0 0 14 0 0 50 0.51 0.17 18 T 0 3 0 -1 -3 2 2 -2 -1 -2 0 2 -1 -3 -2 0 0 -3 -2 -2 6 21 5 0 0 8 19 0 0 0 11 20 0 0 0 5 6 0 0 0 0.30 0.10 19 L -1 2 1 3 -3 1 3 -2 -1 -3 -1 1 -2 -3 -2 0 -1 -4 -3 -3 3 13 8 17 0 6 26 0 0 0 10 8 0 0 0 9 0 0 0 0 0.34 0.11 20 A 5 -3 -3 -3 -2 -2 -2 0 -3 -2 -2 -2 0 2 -2 0 -1 -3 -2 0 76 0 0 0 0 0 0 3 0 0 0 0 3 10 0 0 0 0 0 5 0.66 0.21 21 F -3 -3 -4 -4 -3 -3 -4 -4 -2 -1 1 -4 2 7 -4 -3 -3 0 4 0 0 0 0 0 0 0 0 0 0 0 12 0 6 62 0 0 0 0 12 5 0.96 0.22 22 D 0 2 0 1 -3 2 2 -1 2 -2 -2 1 -2 -3 0 1 0 -3 -2 -2 5 17 3 8 0 11 14 4 6 2 4 5 0 0 3 13 5 0 0 0 0.22 0.07 23 D -1 1 -1 1 -3 2 2 -2 -1 0 1 1 0 -2 -2 0 0 -3 -2 -1 1 11 0 10 0 10 17 2 0 8 19 10 0 0 0 4 4 0 0 3 0.14 0.06 24 V 0 -3 -3 -4 -2 -3 -3 -3 -2 2 2 -3 0 3 -3 -2 0 -2 2 3 8 0 0 0 0 0 0 0 0 14 26 0 0 14 0 0 4 0 7 26 0.31 0.10 25 Y -2 -2 -1 -3 -3 -3 -3 1 -2 -1 0 -3 1 6 -4 -2 -2 2 3 0 0 3 3 0 0 0 0 14 0 0 3 0 5 47 0 0 0 3 10 9 0.54 0.16 26 G -1 -2 -1 -2 -2 -1 -2 3 -2 1 -1 0 0 0 3 -1 -1 -2 -2 -1 2 1 1 1 0 1 1 35 0 12 7 6 3 5 18 2 1 0 1 1 0.33 0.08 27 P 0 1 2 1 -2 1 2 -1 -1 -2 -1 0 1 -2 3 0 -1 -2 -2 -2 8 8 13 9 0 4 15 2 1 1 6 5 6 1 14 2 1 0 1 2 0.20 0.05 28 G 2 -1 -1 2 -2 1 0 2 -1 -2 -1 0 -1 0 -1 0 -1 -2 0 -2 26 3 1 15 0 6 4 17 0 1 4 6 0 6 1 4 1 0 4 1 0.15 0.06 29 Q -1 -1 3 2 -2 2 2 -2 -1 -1 -2 0 -1 -3 -2 1 1 -3 -2 0 1 0 19 16 0 10 13 1 0 3 1 4 2 0 0 11 9 0 0 8 0.26 0.08 30 Y -1 -2 -2 -2 4 -2 -2 -2 -1 2 0 -2 0 2 -2 -1 -1 4 2 2 5 1 1 1 13 1 2 2 1 16 2 1 1 10 1 2 2 7 11 21 0.22 0.07 31 R -1 2 0 2 -2 2 2 -2 2 -1 -2 0 -1 -2 -1 0 0 -2 -1 -1 2 17 1 16 0 10 17 2 9 5 2 1 1 1 1 3 6 0 1 4 0.22 0.06 32 I -1 -4 -4 -4 -2 -3 -4 -4 -4 4 1 -3 0 1 -4 -3 0 -3 -2 4 2 0 0 0 0 0 0 0 0 34 5 0 0 6 0 0 4 0 0 48 0.60 0.18 33 E -1 1 -2 -1 -2 1 3 -3 -2 2 -1 -1 -1 -2 -2 0 1 -3 -2 2 1 8 0 1 0 7 25 0 0 16 0 0 0 0 0 6 8 0 0 28 0.23 0.12 34 G 1 -2 0 -1 -3 -2 -2 5 -2 -4 -4 0 0 -4 2 1 -1 -4 -3 -3 9 0 5 3 0 0 0 49 0 0 0 5 3 0 13 12 0 0 0 0 0.62 0.15 35 V -1 -2 0 -2 -2 -2 1 -3 -3 2 0 -2 2 -2 -3 -2 1 -4 -2 4 2 2 5 0 0 0 13 0 0 13 0 0 6 0 0 0 8 0 0 51 0.35 0.15 36 N 1 -2 2 4 -3 0 2 -1 -1 -4 -4 0 -3 -4 -1 1 -1 -4 -3 -3 14 0 10 34 0 3 18 2 0 0 0 2 0 0 2 15 0 0 0 0 0.49 0.14 37 V 1 0 0 -3 -2 -2 -2 0 -3 1 -1 0 -1 -2 -1 -2 -1 -3 1 4 11 4 5 0 0 0 0 8 0 3 0 7 0 0 3 0 0 0 5 55 0.27 0.15 38 D -1 -2 -1 3 -4 2 2 -2 -2 -2 -3 0 -3 -3 5 -1 -2 -3 0 -3 4 0 0 23 0 9 15 2 0 3 0 7 0 0 29 3 0 0 5 0 0.60 0.14 39 S 0 -2 1 -2 -2 -2 -2 -2 -2 -3 -1 -2 -2 -3 2 5 1 -4 -3 -1 2 0 5 0 0 0 0 0 0 0 8 0 0 0 9 70 3 0 0 3 0.65 0.23 40 G -1 -2 2 0 -3 -1 1 5 -2 -4 -2 -2 -3 -4 -3 1 -1 -4 -3 -3 0 2 9 4 0 0 12 56 0 0 5 0 0 0 0 9 2 0 0 0 0.66 0.16 41 V 0 -3 -3 -4 -2 -3 -3 -4 -4 2 0 -1 0 -2 -3 -2 1 -4 -2 5 6 0 0 0 0 0 0 0 0 12 5 5 0 0 0 0 10 0 0 63 0.54 0.18 42 P 2 -1 -2 0 -3 -2 -2 -1 -3 -3 -3 -2 -3 -4 6 1 0 -4 -3 -2 22 3 0 5 0 0 0 4 0 0 0 0 0 0 49 9 5 0 0 0 0.94 0.18 43 L 0 0 -1 2 -3 2 1 -2 -2 -3 -2 1 -2 -4 5 0 -1 -4 -3 -3 10 3 0 14 0 13 7 0 0 0 5 8 0 0 32 9 0 0 0 0 0.58 0.13 44 Q -3 -1 -2 -2 -5 8 1 -4 1 -5 -4 0 -2 -5 -3 -2 -2 -4 -3 -4 0 0 0 0 0 92 5 0 3 0 0 0 0 0 0 0 0 0 0 0 1.62 0.37 45 P -3 -4 -4 -3 -5 -3 -3 -4 -4 -5 -5 -3 -4 -6 8 -3 -3 -6 -5 -4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 2.75 0.40 46 I -2 -3 -4 -4 -3 -3 -4 -4 -3 2 1 -3 4 5 -4 -2 -2 -2 0 2 0 0 0 0 0 0 0 0 0 17 6 0 15 38 0 3 0 0 0 20 0.58 0.17 47 G -1 -3 -1 -2 0 -2 -2 6 -3 -3 -3 -2 -3 -3 -2 1 1 -3 -3 -3 1 1 0 1 3 0 1 68 0 1 1 1 0 0 1 13 9 0 0 1 0.87 0.18 48 S -1 -2 1 2 3 -1 -1 -2 -1 -1 1 -2 0 -1 0 1 -1 -2 2 0 3 1 7 20 9 0 1 1 0 1 18 1 2 0 3 16 1 0 10 7 0.14 0.08 49 T 1 -1 0 2 -3 1 4 -2 1 -2 -3 0 -2 -3 -2 0 0 -4 -2 -2 16 0 3 10 0 5 43 0 4 3 0 3 0 0 0 6 7 0 0 0 0.43 0.14 50 E 2 -2 -1 2 -3 1 5 -2 -2 -3 -3 -1 -3 -4 -2 -1 -1 -4 -3 -1 21 0 0 10 0 5 56 0 0 0 0 0 0 0 0 0 3 0 0 5 0.65 0.20 51 T -1 -3 -2 -3 -2 -2 -2 1 -3 -1 -2 -2 -2 -3 -3 0 6 -4 -3 2 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 71 0 0 17 0.78 0.24 52 R -1 3 -2 -3 -3 -1 -2 -3 1 1 1 0 2 0 -3 -2 -1 -2 1 2 3 25 0 0 0 0 0 0 5 9 12 6 10 2 0 0 0 0 7 21 0.22 0.11 53 I 0 1 1 -1 -3 2 1 -1 -1 -1 0 2 -1 -3 -2 0 1 -3 -2 0 10 6 8 0 0 15 8 3 0 2 9 20 0 0 0 0 11 0 0 7 0.16 0.08 54 G -1 -4 -2 -3 -4 -3 -4 6 -3 -4 -2 -3 1 -4 -4 -2 -3 1 -4 -4 0 0 0 0 0 0 0 87 0 0 5 0 5 0 0 0 0 3 0 0 1.36 0.27 55 A 6 -3 -3 -3 -2 -2 -2 -1 -3 -3 -3 -2 -2 -4 -2 0 -2 -4 -3 -2 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.20 0.31 56 R -2 3 -2 -3 -3 1 -2 -3 -2 2 1 0 0 -2 -3 -2 1 -3 -2 1 0 29 0 0 0 9 0 0 0 24 13 4 0 0 0 0 10 0 0 10 0.28 0.12 57 Q -1 -1 5 0 -4 3 3 -2 -1 -4 -4 1 -3 -4 -3 -1 -1 -4 -3 -2 5 0 47 0 0 15 22 0 0 0 0 5 0 0 0 0 3 0 0 3 0.68 0.20 58 R -3 8 -2 -3 -5 -1 -2 -4 -2 -5 -4 1 -3 -5 -4 -2 -3 -4 -3 -4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.78 0.36 59 V 4 -3 -3 -3 -2 -2 -3 -2 -3 1 -1 -2 -1 -3 -2 -1 -1 -4 -3 3 55 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 35 0.58 0.21 60 K -1 2 1 1 -3 0 0 -2 1 -1 0 3 3 -2 -2 -1 -1 -3 -1 -1 3 15 8 9 0 0 1 0 5 1 6 25 18 0 0 1 0 0 2 4 0.22 0.12 61 N 1 0 4 -1 -3 0 0 -2 3 -3 -3 0 0 -2 -2 1 -1 -2 2 -2 12 5 37 0 0 2 7 1 9 0 1 4 3 0 0 8 0 0 10 0 0.37 0.13 62 A 5 -3 -3 -3 5 -2 -2 -1 -3 -2 0 -2 -2 -3 -2 0 -1 -3 -3 -1 71 0 0 0 13 0 0 0 0 0 8 0 0 0 0 0 0 0 0 3 0.72 0.23 63 R -1 4 -2 -3 -3 1 -1 -3 -2 0 2 1 0 0 -3 -2 -2 -2 1 0 3 31 0 0 0 7 0 0 0 7 28 8 0 4 0 0 0 0 5 4 0.26 0.11 64 Q 0 3 0 -1 -1 4 2 -2 -1 -2 -2 2 0 -3 -2 1 -1 -3 -2 -2 8 20 2 0 1 26 12 0 0 2 4 10 3 0 0 12 0 0 0 0 0.36 0.13 65 V 2 -1 0 -2 0 0 -1 -1 -2 0 0 -1 0 0 -1 1 0 -2 -1 1 26 3 4 1 2 5 3 1 0 1 11 3 2 5 1 9 3 0 1 19 0.08 0.05 66 R 0 2 0 -1 -1 0 -1 -1 1 1 0 1 0 -1 -2 -1 0 1 -1 0 5 18 5 3 1 2 1 3 5 13 11 9 2 0 1 1 8 3 0 8 0.06 0.05 67 P 1 -1 0 0 -2 1 0 0 2 -2 -2 0 -2 -3 5 0 -1 -3 -2 -1 11 1 4 5 0 6 4 7 8 1 2 4 0 1 34 3 3 0 1 4 0.50 0.10 68 E -2 0 3 4 -4 2 3 1 -1 -4 -4 0 -3 -4 -3 -1 -1 -4 0 -4 0 3 16 29 0 9 26 10 0 0 0 2 0 0 0 0 2 0 4 0 0.57 0.17 69 A 4 -2 1 -2 2 -2 -2 0 -2 -2 -3 0 -2 -1 -2 1 0 -3 -1 -1 54 0 8 0 6 0 0 4 0 0 0 8 0 3 0 7 4 0 2 4 0.39 0.18 70 D -2 -2 0 6 -4 1 2 -3 -2 -4 -4 -1 -3 -4 -3 -1 0 -4 0 -4 2 0 2 61 0 8 12 0 0 0 0 0 0 0 0 3 6 0 4 0 0.91 0.23 71 F -3 -3 -3 -4 -4 -3 -3 -4 4 1 -1 -3 -2 5 -1 -3 -1 0 6 -2 0 0 0 0 0 0 0 0 11 11 2 0 0 34 4 0 4 0 34 0 0.89 0.24 72 W 1 -3 -2 -3 -3 -3 -3 4 -2 -4 -4 -3 -3 -1 -3 1 -2 7 3 -3 14 0 0 0 0 0 0 41 0 0 0 0 0 0 0 11 0 19 15 0 0.88 0.23 73 V -2 -4 -5 -5 -2 -4 -4 -5 -5 2 0 -4 -1 1 -4 -3 -2 -4 -2 6 0 0 0 0 0 0 0 0 0 10 5 0 0 7 0 0 0 0 0 79 0.97 0.28 74 G 2 -4 -2 -3 -3 -3 -3 6 -3 -5 -5 -3 -4 -4 -3 0 -2 -4 -4 -4 16 0 0 0 0 0 0 77 0 0 0 0 0 0 0 8 0 0 0 0 1.28 0.28 75 I -2 -4 -4 -5 -2 -4 -4 -5 -4 5 2 -4 2 -1 -4 -3 -2 -4 -2 3 0 0 0 0 0 0 0 0 0 53 19 0 7 0 0 0 0 0 0 21 0.78 0.22 76 E -3 -2 -2 0 -6 0 7 -4 -2 -5 -5 -1 -4 -5 -3 -2 -3 -5 -4 -5 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 1.78 0.42 77 A 4 -3 0 -3 -2 -2 -2 3 -3 -3 -3 -2 -3 -4 -2 2 -1 -4 -3 -2 57 0 4 0 0 0 0 25 0 0 0 0 0 0 0 14 0 0 0 0 0.72 0.23 78 G -2 -4 -2 -3 -4 -4 -4 7 -4 -5 -5 -3 -4 1 -4 -2 -3 -4 -4 -5 0 0 0 0 0 0 0 92 0 0 0 0 0 8 0 0 0 0 0 0 1.67 0.34 79 I -2 -4 -4 -4 -2 -4 -4 -5 -4 5 2 -4 0 -2 0 -3 -2 -4 -3 4 0 0 0 0 0 0 0 0 0 51 14 0 0 0 4 0 0 0 0 32 0.76 0.22 80 E 0 -2 -1 3 3 0 3 -3 1 0 -2 -1 0 -1 -2 -1 0 -3 -1 1 7 0 0 21 7 2 24 0 4 8 0 0 4 3 0 0 5 0 2 13 0.23 0.12 81 D 0 0 1 3 -4 0 3 2 2 -3 -3 0 -3 -1 -2 -1 -2 -3 0 -2 6 6 5 19 0 0 25 17 8 0 0 4 0 3 0 0 0 0 4 3 0.33 0.12 82 N -2 -2 3 2 -3 -2 0 1 -1 -2 0 -2 -2 1 1 0 -1 -2 2 -1 0 0 22 12 0 0 4 14 0 0 11 0 0 8 7 7 0 0 12 5 0.20 0.11 83 M 0 -2 -2 -2 -2 -1 1 0 -2 0 -1 0 2 2 0 1 -1 -2 -1 1 9 0 0 0 0 0 14 6 0 5 3 9 9 17 4 11 1 0 0 11 0.09 0.09 84 T 0 0 0 3 -3 -2 -1 0 -2 -2 -1 -2 -2 1 -3 -1 4 -3 1 -2 7 4 3 21 0 0 0 8 0 0 4 0 0 9 0 0 37 0 7 0 0.32 0.16 85 F -3 -4 -3 -4 -3 -3 -4 -2 2 2 0 -4 -1 6 -4 -2 -3 -1 3 -1 0 0 0 0 0 0 0 4 8 19 7 0 0 47 0 4 0 0 11 0 0.71 0.21 86 A 3 -2 -2 -1 -2 0 -2 1 3 -2 0 -2 -1 -2 -2 1 -1 -3 0 0 36 0 0 3 0 5 0 12 12 0 14 0 0 0 0 8 2 0 4 6 0.22 0.13 87 W -3 -4 0 0 5 -3 -3 -1 -2 -1 -1 -3 -2 2 -4 -3 -3 9 3 0 0 0 5 6 15 0 0 6 0 3 3 0 0 9 0 0 0 32 11 9 0.94 0.23 88 M 2 -3 -1 -3 4 -2 -3 -3 -3 2 1 -3 4 -1 -3 -1 0 -3 1 2 21 0 4 0 11 0 0 0 0 13 8 0 18 0 0 0 3 0 6 16 0.29 0.14 89 V 1 -3 -3 -4 -2 -3 -2 -3 -4 2 0 -3 -1 -2 -3 -2 1 2 -2 5 14 0 0 0 0 0 3 0 0 12 4 0 0 0 0 0 8 4 0 56 0.51 0.20 90 V -1 -1 -4 -4 -2 -3 -1 -2 -4 4 0 -3 0 -2 -4 -3 -2 -4 -3 4 3 3 0 0 0 0 4 4 0 37 0 0 0 0 0 0 0 0 0 49 0.63 0.22 91 E 1 -1 -1 3 -3 0 3 -1 -1 -3 -3 0 -2 0 -2 0 0 -2 2 -3 17 3 0 17 0 0 32 3 0 0 0 3 0 5 0 4 4 0 12 0 0.36 0.15 92 H 0 2 2 3 -3 1 0 -2 3 -2 -2 -1 -2 -3 -2 0 -1 -4 -1 -1 11 12 13 23 0 8 0 0 11 0 4 0 0 0 0 8 0 0 1 8 0.28 0.13 93 L 0 -1 -1 -1 -2 0 0 1 3 1 -1 -1 -1 1 0 -1 0 -2 -1 1 8 1 0 3 0 7 6 15 11 12 3 3 0 8 4 0 7 0 0 11 0.06 0.06 94 Q 1 -2 0 1 -3 1 0 3 -1 -2 -2 0 -2 -3 -2 0 1 -3 -3 -1 14 0 4 7 0 10 7 32 1 0 4 3 0 0 0 2 12 0 0 4 0.29 0.11 95 A -1 2 1 2 -3 2 0 -2 1 0 -1 1 -1 -2 0 -1 -1 0 -1 -1 6 17 10 13 0 13 0 0 5 10 5 7 0 0 4 0 3 1 2 3 0.15 0.09 96 R -2 4 -2 -2 2 1 2 -3 2 0 0 0 -1 -3 -3 -2 -1 -4 -2 1 0 35 0 0 5 4 17 0 7 8 7 3 0 0 0 0 2 0 0 12 0.34 0.15 97 G -1 -3 1 -2 -3 -2 -3 4 -3 -3 -1 -2 -2 -3 -3 1 3 2 -3 -2 3 0 6 0 0 0 0 41 0 0 8 0 0 0 0 7 31 4 0 0 0.57 0.19 98 E -2 1 -2 0 -3 -1 3 -1 -2 2 1 -1 -1 -2 -3 -2 0 -4 -3 1 0 8 0 4 0 0 34 6 0 16 12 0 0 0 0 0 6 0 0 14 0.24 0.14 99 S 3 -3 -2 -2 -3 -2 -3 5 -3 -4 -4 -2 -3 -4 -3 2 -1 -4 -4 -3 29 0 0 0 0 0 0 50 0 0 0 0 0 0 0 21 0 0 0 0 0.85 0.23 100 R -2 4 -2 -3 0 -1 -2 -1 0 0 0 -1 3 3 -3 0 0 -2 -1 -1 0 34 0 0 2 0 0 4 2 5 5 0 11 21 0 8 5 0 0 2 0.33 0.16 101 S -1 -3 -1 -2 -3 -2 -2 3 -3 -4 -4 -2 -3 -4 -3 5 1 -4 -4 -3 0 0 0 0 0 0 0 28 0 0 0 0 0 0 0 65 8 0 0 0 0.90 0.28 102 A 4 -2 -2 -2 -2 2 -2 -1 -3 -3 -3 -2 0 -4 4 2 -1 -4 -3 -2 42 0 0 0 0 10 0 3 0 0 0 0 3 0 25 17 0 0 0 0 0.68 0.21 103 S 2 1 -1 -2 0 -2 -2 3 -2 -2 -2 -1 -2 -3 -2 2 1 2 -3 -2 24 8 0 0 1 0 0 22 0 3 4 0 0 0 0 26 8 3 0 0 0.33 0.14 104 L -3 -4 -4 -5 -3 -4 -4 -5 -3 0 3 -4 0 6 -4 -3 0 -1 0 0 0 0 0 0 0 0 0 0 0 4 32 0 0 52 0 0 8 0 0 4 0.87 0.24 105 M -2 -2 -2 -2 -4 3 3 -3 -2 -3 -3 0 3 -4 4 0 0 -4 -3 -1 0 0 0 0 0 16 24 0 0 0 0 5 13 0 26 5 7 0 0 3 0.65 0.25 106 L -2 -4 -5 -5 1 -4 -4 -5 -3 3 4 -4 0 -1 -4 -4 -2 -3 2 2 0 0 0 0 4 0 0 0 0 19 50 0 0 0 0 0 0 0 11 17 0.66 0.23 107 P -3 -5 -4 1 -5 -4 -3 -5 -5 -5 -5 -3 -5 -6 8 -3 -4 -6 -5 -5 0 0 0 8 0 0 0 0 0 0 0 0 0 0 92 0 0 0 0 0 2.65 0.53 108 D 0 1 0 2 -3 0 1 -2 -2 -3 -1 0 0 -3 4 0 0 -3 0 -2 9 9 5 12 0 3 12 0 0 0 5 4 4 0 21 5 6 0 5 0 0.32 0.12 109 I 1 1 0 1 -2 2 0 -1 0 1 -1 0 0 -2 -1 1 0 -3 -2 0 13 10 2 7 0 12 6 3 2 13 3 2 2 0 2 13 3 0 0 8 0.09 0.08 110 I -1 -4 -4 -5 -3 -4 -4 -5 -4 4 0 -4 3 3 -4 -3 -2 -3 1 4 2 0 0 0 0 0 0 0 0 25 3 0 8 17 0 0 0 0 3 42 0.67 0.24 111 L -1 -3 -4 -4 -2 -3 -1 -4 -3 2 4 -3 2 -1 -4 -3 -1 -3 1 2 5 0 0 0 0 0 5 0 0 8 49 0 4 0 0 0 3 0 6 21 0.48 0.19 112 Q 1 1 0 1 -3 2 3 -1 3 -4 -4 1 -2 -4 1 0 -1 -4 -2 -3 13 7 4 8 0 13 23 2 9 0 0 8 0 0 6 7 0 0 0 0 0.36 0.15 113 G 0 1 0 2 -3 2 2 2 1 -3 0 1 -2 -3 -2 -1 -2 -3 -2 -3 6 7 2 13 0 10 15 17 5 0 15 10 0 0 0 0 0 0 0 0 0.23 0.12 114 I -1 -3 -4 -4 -2 -3 -4 -4 -4 4 2 -3 3 -1 -4 -3 -1 -3 -2 4 3 0 0 0 0 0 0 0 0 27 21 0 12 0 0 0 0 0 0 36 0.56 0.16 115 R -2 3 -2 -2 -3 0 1 -4 -1 -1 3 1 1 -2 -1 -2 -2 -3 -2 -1 2 20 0 0 0 3 11 0 2 0 46 11 4 0 2 0 0 0 0 0 0.32 0.13 116 Q 1 3 0 1 -3 3 2 -1 -1 -3 -3 2 -2 -4 -2 0 0 -3 -3 -3 13 17 2 7 0 18 16 4 0 0 0 11 0 0 0 6 6 0 0 0 0.34 0.10 117 G 0 -3 0 1 -4 -3 -3 6 -3 -5 -5 -3 -4 -5 -3 -1 -3 -4 -4 -4 5 0 4 10 0 0 0 81 0 0 0 0 0 0 0 0 0 0 0 0 1.28 0.24 118 R -2 4 -1 -1 -3 0 1 -3 -2 1 -1 2 1 -3 -3 -1 -1 -4 -2 1 0 28 3 1 0 0 14 0 0 10 0 20 7 0 0 0 0 0 0 17 0.31 0.12 119 E 0 -2 -2 0 -4 0 6 -3 -2 -4 -4 -1 -3 -4 -2 0 0 -4 -3 -3 9 0 0 0 0 0 80 0 0 0 0 0 0 0 0 7 4 0 0 0 1.02 0.25 120 L -2 -3 -4 -4 -2 -3 -3 -2 -3 1 4 -3 2 2 -3 -3 -2 -2 -1 2 0 0 0 0 0 0 0 4 0 0 65 0 3 11 0 0 0 0 0 14 0.52 0.14 121 G -1 -3 0 -2 -3 -2 -3 6 -3 -4 -4 -2 -3 -4 -3 1 -2 -3 -4 -4 0 0 4 0 0 0 0 80 0 0 0 0 0 0 0 11 0 0 0 0 1.18 0.21 122 D -1 -1 0 4 -3 1 3 -2 2 -2 -3 0 -2 -3 2 -1 -1 -4 -2 -1 6 0 0 31 0 7 25 0 6 3 0 3 0 0 10 2 0 0 0 5 0.44 0.11 123 E 2 -2 -3 -2 -2 -2 1 -2 -3 2 1 -2 0 -2 -2 -1 0 -3 -2 3 23 0 0 0 0 0 11 0 0 7 13 0 0 0 0 0 3 0 0 39 0.25 0.11 124 M 1 -3 -3 -4 -3 -2 -3 -3 -2 -1 0 -3 7 0 -3 -1 0 -2 3 0 15 0 0 0 0 0 0 0 0 0 0 0 59 3 0 5 4 0 11 4 0.74 0.24 125 A 1 -2 0 4 -3 0 4 1 -2 -4 -4 -1 -3 -4 -2 2 -1 -4 -3 -3 12 0 0 27 0 0 33 10 0 0 0 0 0 0 0 18 0 0 0 0 0.54 0.15 126 V -1 3 -1 0 -3 2 2 -1 -1 -1 -1 2 -1 -2 -2 0 0 -3 -1 -1 4 19 0 4 0 9 17 4 0 5 4 21 0 1 0 4 5 0 2 2 0.23 0.07 127 L -1 -3 -3 -4 -2 -2 -3 -4 2 2 2 -3 1 0 -3 -2 -2 1 4 2 5 0 0 0 0 1 0 0 6 13 30 0 3 0 0 0 0 1 26 14 0.38 0.12 128 S -1 -3 -2 -3 -2 -2 -3 -3 -2 1 0 -2 -1 4 -3 1 3 -1 2 1 4 0 0 0 0 0 0 0 0 7 4 0 0 30 0 12 26 0 6 11 0.34 0.13 129 G -1 -2 3 1 -4 -1 0 5 -2 -4 -4 2 -3 -4 -3 0 -2 -4 -4 -4 0 0 15 7 0 0 4 55 0 0 0 15 0 0 0 4 0 0 0 0 0.73 0.16 130 I -1 0 1 -1 -2 0 -2 -3 -2 3 -1 0 -1 -2 -3 -1 3 -4 -2 2 0 7 8 3 0 3 0 0 0 25 0 8 0 0 0 0 25 0 0 21 0.22 0.11 131 S -1 0 1 2 -3 2 2 -2 -1 -2 -3 2 -2 -4 3 0 -1 -4 -3 -1 4 3 9 17 0 9 14 0 0 2 0 14 0 0 18 3 0 0 0 6 0.38 0.09 132 N 0 -2 5 3 -4 0 2 1 -1 -4 -4 -1 -3 -4 -2 0 -1 -4 -3 -3 7 0 38 15 0 2 21 12 0 0 0 0 0 0 0 5 0 0 0 0 0.57 0.15 133 V -1 -3 -3 -4 -2 -3 -3 -4 -4 5 2 -3 0 -1 -3 0 -1 -3 -2 3 4 0 0 0 0 0 0 0 0 49 16 0 0 0 0 9 0 0 0 22 0.50 0.15 134 K -1 1 0 1 -4 -1 -1 4 -2 -4 -4 4 -3 -4 -3 0 -2 -4 -3 -4 0 4 2 11 0 0 0 44 0 0 0 36 0 0 0 4 0 0 0 0 0.65 0.16 135 Q -2 3 -1 1 -4 4 1 -3 2 -3 -3 2 0 -2 -2 -1 0 -2 2 -3 0 19 0 7 0 27 5 0 4 0 0 17 4 0 0 0 5 0 12 0 0.42 0.13 136 Q -1 2 0 -1 -3 1 0 -1 1 -4 -3 4 -2 -4 -2 1 0 -4 -2 -3 0 13 3 0 0 4 3 4 4 0 0 50 0 0 0 16 4 0 0 0 0.51 0.15 137 G -1 -1 -1 1 -3 0 4 2 -2 0 -2 -1 -1 -3 -2 0 0 -4 -3 0 0 3 0 4 0 0 42 22 0 10 0 0 2 0 0 3 7 0 0 8 0.34 0.13 138 G -1 -4 -2 -3 -4 -3 -4 7 -4 -5 -5 -3 -4 -5 -4 -2 -3 -4 -5 -5 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 1.76 0.29 139 A 4 -3 -3 -3 -2 -2 -3 -2 -3 2 0 -2 -1 1 -2 -1 -1 -3 -2 0 65 0 0 0 0 0 0 0 0 20 6 0 0 9 0 0 0 0 0 0 0.51 0.18 140 I -2 -4 -5 -5 -2 -4 -4 -5 -5 6 0 -4 0 -2 -4 -4 -2 -4 -3 3 0 0 0 0 0 0 0 0 0 80 0 0 0 0 0 0 0 0 0 20 1.02 0.24 141 G 0 -3 -2 -3 -4 -3 -3 6 0 -5 -5 -3 -4 -4 -3 0 -3 -4 -4 -4 3 0 0 0 0 0 0 89 3 0 0 0 0 0 0 5 0 0 0 0 1.41 0.24 142 I -1 -2 -3 -4 -2 -2 -3 -4 -2 2 2 0 1 2 -3 -2 -1 -1 3 2 1 0 0 0 0 0 0 0 0 11 23 11 3 7 0 0 0 0 17 27 0.30 0.11 143 F -1 -3 -4 -4 -2 -3 -4 -4 -3 2 4 -4 1 4 -4 -3 -2 -2 0 0 5 0 0 0 0 0 0 0 0 11 57 0 0 27 0 0 0 0 0 0 0.63 0.16 144 T -1 -2 -1 -2 -2 -2 -2 -3 -3 -2 -3 -2 -2 -4 -2 3 6 -4 -3 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 26 74 0 0 0 1.00 0.26 145 Q 0 2 3 2 -3 1 1 0 2 -4 -3 2 -2 -4 -2 0 -1 -4 -2 -3 8 16 22 15 0 5 4 6 6 0 0 13 0 0 0 5 0 0 0 0 0.35 0.09 146 G -1 0 2 -2 -4 0 -2 6 1 -4 -4 -2 -3 -4 -3 -1 -2 -4 -3 -4 0 5 12 0 0 4 0 72 4 0 0 0 0 0 0 0 0 0 0 0 0.99 0.19 147 K 0 2 0 -2 -2 0 0 -2 2 0 0 2 1 -2 -2 -1 0 -3 -2 1 12 17 3 0 0 3 4 0 7 4 13 19 5 0 0 0 3 0 0 12 0.13 0.07 148 L -1 -3 -4 -4 -2 -3 -4 -4 -4 3 3 -3 1 -1 -3 -3 -1 -3 -2 3 4 0 0 0 0 0 0 0 0 27 40 0 0 0 0 0 0 0 0 29 0.54 0.14 149 T -1 2 0 1 -2 -1 -1 -2 -2 -2 -2 1 -2 -3 -2 2 4 -4 -3 -1 0 11 2 7 0 0 0 0 0 0 3 9 0 0 0 17 48 0 0 3 0.43 0.15 150 R -3 8 -2 -3 -5 0 -2 -4 -2 -5 -4 1 -3 -5 -4 -2 -3 -4 -3 -4 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.72 0.33 151 T -1 -1 -1 -2 -2 1 1 -2 -1 0 -1 2 -1 0 -2 1 2 -2 2 -1 0 0 0 0 0 5 7 0 0 11 2 22 0 2 0 16 20 0 12 3 0.19 0.10 152 S 0 -2 1 4 -3 0 2 -1 0 -3 -3 -1 -1 -4 -2 3 0 -4 -3 -3 4 0 4 35 0 4 10 4 3 0 0 0 2 0 0 30 4 0 0 0 0.48 0.13 153 V -2 -3 0 -4 -2 -3 -3 -4 -3 1 4 -3 3 -1 -4 -3 -2 -3 -2 3 0 0 7 0 0 0 0 0 0 0 57 0 8 0 0 0 0 0 0 28 0.55 0.16 154 Y -2 -3 3 -2 2 -2 -3 -3 0 1 -2 -2 -2 2 -4 -1 1 0 6 -1 0 0 19 0 6 0 0 0 0 11 0 0 0 8 0 3 10 0 44 0 0.60 0.18 155 H -2 1 -1 -1 -3 2 2 -3 5 -1 -1 0 2 -2 -3 -1 1 -3 0 0 0 10 0 0 0 9 17 0 22 4 5 3 9 0 0 0 11 0 3 7 0.26 0.11 156 Q 0 -1 -1 -1 -4 5 3 -3 4 -1 -1 0 -2 -3 -3 -1 -2 -3 -2 -2 9 0 0 0 0 45 18 0 16 3 6 0 0 0 0 0 0 0 0 2 0.60 0.19 157 A 4 -3 -2 -3 4 -2 -2 0 -3 -2 -2 -2 -2 -3 2 1 -1 -4 -3 0 59 0 0 0 9 0 0 3 0 0 0 0 0 0 9 13 0 0 0 8 0.53 0.17 158 L -2 -4 -4 -4 -2 -3 -4 -4 -4 3 2 -3 0 -1 -4 -3 0 -4 -2 4 0 0 0 0 0 0 0 0 0 23 19 0 0 0 0 0 3 0 0 55 0.63 0.17 159 L 0 0 -3 -3 -2 -2 -3 -4 0 4 2 -2 0 -1 -3 -2 0 -3 0 2 7 7 0 0 0 0 0 0 4 40 22 0 0 0 0 0 7 0 4 9 0.28 0.11 160 L -1 -3 0 -4 -3 -2 -3 -4 -3 0 4 -3 6 -1 -4 -3 -2 -3 -2 0 4 0 7 0 0 0 0 0 0 0 49 0 40 0 0 0 0 0 0 0 0.75 0.21 161 A 6 0 -3 -3 -2 -2 -2 -1 -3 -2 -1 -2 -2 -3 -2 0 -1 -4 -3 -1 89 5 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0.85 0.23 162 L -2 -3 -4 -5 -2 -3 -4 -5 -4 1 5 -3 3 2 -4 -3 -2 -2 -1 0 0 0 0 0 0 0 0 0 0 6 78 0 9 7 0 0 0 0 0 0 0.78 0.18 163 V 0 -3 -2 -1 0 -2 -2 -3 -2 3 1 -2 1 -1 -3 0 -1 -2 2 2 8 0 0 6 1 0 0 0 0 36 6 0 4 0 0 10 0 0 9 20 0.23 0.09 164 P -2 -3 -3 -3 -4 -3 -2 -4 -4 -4 -4 -1 -4 -5 8 -2 -3 -5 -4 -4 0 0 0 0 0 0 0 0 0 0 0 4 0 0 96 0 0 0 0 0 2.46 0.29 165 F -3 2 -3 -4 -3 -2 -3 -4 2 0 -1 -2 -1 6 -4 -3 -3 3 1 -1 0 20 0 0 0 0 0 0 6 6 2 0 0 58 0 0 0 5 0 3 0.72 0.16 166 H -2 -2 3 -2 -3 -1 -2 -3 5 0 1 -2 2 0 -3 -1 0 -1 4 -1 0 0 20 0 0 0 0 0 22 6 13 0 10 0 0 0 5 0 24 0 0.41 0.12 167 N 0 -1 6 3 -3 -1 -1 -1 2 -4 -4 0 -3 -4 -3 0 -1 -4 -3 -3 11 0 59 14 0 0 0 0 6 0 0 6 0 0 0 4 0 0 0 0 0.72 0.15 168 E 1 -1 -1 2 -3 1 2 -2 -2 -3 -3 1 -2 -4 4 1 1 -4 -3 -2 11 0 0 11 0 7 17 0 0 0 0 10 0 0 23 6 14 0 0 0 0.45 0.08 169 I -2 -3 -3 -3 -2 -2 -3 -4 0 4 2 -3 3 -1 -3 -2 1 -3 -2 2 0 0 0 0 0 0 0 0 4 39 26 0 10 0 0 0 16 0 0 6 0.34 0.09 170 Y -3 -3 -3 -4 -4 -3 -3 -4 1 -2 -2 -3 -2 2 -4 -3 -3 1 8 -2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 1.67 0.21 171 Q 0 4 -1 -1 -3 3 1 -2 -1 -2 -1 1 -1 -3 -2 0 2 -3 -2 -2 6 37 0 0 0 17 8 0 0 0 5 7 0 0 0 0 20 0 0 0 0.38 0.07 172 R -1 3 -1 -1 -3 3 0 -2 -1 -1 -2 2 -1 -3 4 -1 -1 -3 -2 -2 0 20 0 0 0 29 0 0 0 6 0 21 0 0 25 0 0 0 0 0 0.56 0.06 173 P -1 -2 -2 -2 -3 -1 -1 -2 -2 -3 -3 1 -3 -4 8 -1 -1 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 11 0 0 89 0 0 0 0 0 1.83 0.06 174 S 3 -1 0 -1 -1 2 0 0 -1 -2 -2 0 -1 -3 -1 2 0 -3 -2 -1 42 0 0 0 0 22 0 0 0 0 0 0 0 0 0 36 0 0 0 0 0.30 0.00 175 P 2 -2 -2 -2 -2 -1 -1 -1 -2 -2 -2 -1 -2 -3 7 0 -1 -3 -3 -1 37 0 0 0 0 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0 1.12 0.00 176 S 3 -1 0 -1 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 3 1 -3 -2 -1 37 0 0 0 0 0 0 0 0 0 0 0 0 0 0 63 0 0 0 0 0.36 0.00 177 K -1 2 0 -1 -3 1 1 -2 -1 -3 -3 5 -1 -3 -1 0 -1 -3 -2 -2 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0.51 0.00 178 P -1 -2 -2 -2 -3 -1 -1 -2 -2 -3 -3 -1 -3 -4 8 -1 -1 -4 -3 -3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 2.04 0.00 179 A 4 -2 -2 -2 0 -1 -1 0 -2 -1 -2 -1 -1 -2 -1 1 0 -3 -2 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.40 0.00 180 I -1 -3 -3 -3 -1 -3 -3 -4 -3 4 2 -3 1 0 -3 -2 -1 -3 -1 3 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 0 0.38 0.00 K Lambda Standard Ungapped 0.1356 0.3188 Standard Gapped 0.0455 0.2670 PSI Ungapped 0.1487 0.3192 PSI Gapped 0.0455 0.2670